How To Spend 48 Hours In Rome

March 26, 2025

Steeped in history and pulsating with modern allure, Rome is a city that captivates at every turn. In just 48 hours, you can journey through millennia—wandering ancient ruins, indulging in world-class cuisine, and immersing yourself in the effortless elegance of la dolce vita. This carefully curated itinerary ensures that every moment is spent savoring the Eternal City’s most unforgettable experiences.

Friday PM

After touching down in Rome, hop into a taxi and head straight to your home for the weekend—the storied and effortlessly elegant Palazzo Talia. A seamless blend of historic grandeur and modern sophistication, this reimagined Roman retreat offers an atmosphere of understated luxury. With impeccable design, bespoke details, and an effortlessly chic allure, Palazzo Talia is the ultimate destination for a refined stay in the Eternal City.

After settling into your impeccably designed suite—perhaps unwinding with a soak in the sculptural freestanding tub or admiring the sleek marble finishes—it’s time for an aperitivo. Over the next two evenings, you’ll have plenty of opportunities to experience both the tranquil courtyard and the panoramic rooftop, but for now, start in the elegant lounge. Order a signature Negroni and take in the effortless glamour of Palazzo Talia, as a mix of well-heeled travelers and in-the-know locals create the perfect Roman atmosphere.

Then, take a leisurely 15-minute stroll to your dinner reservation at La Matricianella, pausing to admire the city's architectural splendor along the way. Once seated, indulge in classic Roman specialties—crispy fried artichokes and a rich, perfectly balanced bowl of Amatriciana—paired with a velvety Tuscan red.

Saturday AM

First things first: breakfast in the serene courtyard of Palazzo Talia. A perfectly frothed cappuccino, freshly squeezed orange juice, a basket of delicate mini pastries, seasonal fruit, and eggs made to order—it’s the ideal start to the day.

From here, take a short stroll to the Borghese Gardens, arguably the most beautiful in Rome. As you pass through Piazza del Popolo, pause to admire the soaring Baroque grandeur of the Basilica di Santa Maria in Montesanto. Meander through the gardens, letting the city unfold beneath you from one of its most breathtaking vantage points, before arriving at the Borghese Gallery. Here, set aside a couple of hours to immerse yourself in one of Rome’s most exquisite collections, where masterpieces by Raphael, Caravaggio, and Bernini await.

Picture by Caleb Miller

Next, it’s time for lunch. Be sure to reserve a table at Roscioli, a beloved deli-turned-restaurant that’s equally adored by discerning locals and savvy visitors. Savor a selection of expertly curated dishes—think anchovy-topped bruschetta, rich caponata, and iconic Roman staples like cacio e pepe.

Saturday PM

If you’re craving a dose of culture and a glimpse of breathtaking frescoed ceilings, step into either Chiesa San Luigi dei Francesi or the opulent Palazzo Doria Pamphilj. Otherwise, take a leisurely stroll from Roscioli across the Tiber into the relaxed, bohemian streets of Trastevere, where an afternoon of spritz stops and aimless wandering awaits.

As the evening approaches, return to Palazzo Talia for a cocktail on its stunning rooftop—one of the most enchanting vantage points in Rome. Be sure to reserve in advance, as this coveted spot fills up quickly. Then, hop in a taxi back to Trastevere for dinner at Da Enzo, a favorite of hotelier Marie-Louise Sciò. No reservations are taken, but this effortlessly charming trattoria, with its alfresco tables and perfectly executed Roman classics, is well worth the wait. For a nightcap, seek out Jerry Thomas—just don’t forget the password to get inside.

Sunday AM

After a relaxed morning at home, make your way to Villa Medici, perched on Monte Pincio just steps from the Spanish Steps. Once the grand residence of the Medici family, it now houses the French Academy, yet its exquisite interiors and sprawling gardens remain open for exploration with a guided tour. Discover hidden chambers, ornate frescoes, and striking sculptures, all culminating in a breathtaking view over Rome.

Before departing, there’s time for one last meal. Stroll down the Spanish Steps to Pianostrada, a stylish hideaway tucked along a quiet side street. With its sleek, modern aesthetic and charming courtyard, it’s the perfect spot for a final indulgence—whether it’s a handcrafted panino, crisp fritti, or one last plate of expertly made pasta, all sourced from the finest local ingredients.

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Where to EAT

  • Pierluigi: For a sophisticated al fresco dining experience in one of Rome’s most refined, hidden squares, Pierluigi delivers both charm and culinary excellence. Celebrated for its impeccable seafood, this lively yet upscale ristorante is a destination for those seeking the finest flavors of the sea. With a menu that shifts with the seasons, each visit offers something new and memorable. Trust the kitchen and opt for the daily catch—it’s always the standout choice.

Price: €€€ | Go for: For the freshest catch of the day | Location: Piazza de' Ricci 144

  • La Matricianella: Just around the corner from one of our favorite spots, J.K. Place Roma, Matricianella offers an authentic taste of old-school Roman dining. With its white tablecloths, rustic wooden tables, and walls adorned with family photos and bottles of Sassaica, it exudes a warm, homely charm. The staff speaks only Italian and prefers you to make a reservation, even for lunch. This is the true essence of Rome, after all. While the daily specials, sourced from nearby markets, are always a great choice, you can’t go wrong with their artichokes, pasta, and meats. If you’re lucky enough to book a table in advance, outdoor seating is an especially sought-after experience.

Price: €€ | Go for: A Roman lunch | Location: Via del Leone 4

  • Settimio all'Arancio: A true classic in the heart of the old town, Settimio all'Arancio is just a short walk from J.K. Place Roma. Tucked away on a peaceful side street, it offers a delightful selection of fresh fish and traditional Roman dishes in a charming, off-the-beaten-path setting.

Price: €€ | Go for: Go for an intimate dinner | Location: Via dell'Arancio, 50

And a Few More for Your List

  • Da Enzo, Via Ennio Quirino Visconti, 39
  • Pianostrada (lunch), Via delle Zoccolette, 22

Let Us Curate Your Journey

Our dedicated team at Bonvivant Travel specializes in crafting personalized itineraries that align with your desires. With exclusive access to these remarkable properties and experiences, we ensure every aspect of your journey is meticulously planned and flawlessly executed.

Contact us today to begin designing your bespoke roman escape.

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